M.A. Thesis:

Synthesis of bio Nano hydrogel based on Chitosan and magnetic Cu-Fe bimetals nanoparticles coated with silica gel and its swelling ratio and drug delivery

Chitosan is currently receiving enormous interest for medical and pharmaceutical applications due to its biocompatibility in animal tissues, biodegradability and its degradation products are nontoxic, non-immunogenic and non-carcinogenic. Chitosan based hydrogels have good biocompatibility, low degradation and processing ease yielding well-defined physicochemical properties and easily reproducible drug release profiles. Molecular imprinting (MIP) is a technique for preparing recognition sites with predetermined selectivity which is tailor-madein situ by copolymerization of functional monomers and cross linkers in the presence of the template molecule. MIPs possess with several advantages, are appealing as drug delivery vehicles. The main objective of this study, was to design a bio-nano-hydrogels with magnetic properties that can be used in drug delivery. For this, chitosan was chosen for the main base of hydrogel and to create the magnetic properties in this, the hydrogel was combined with CuFe2O4 nanoparticles. To achieve this, multi-step synthesis was designed (Scheme 1). In the first, the magnetic nanoparticles was prepared by sol-gel method and its surface was coated with silica [5]. Next, the vinyl groups was placed to the surface of the nanoparticles, and also on Chitosan. Finally, the hydrogel was more crosslinked and magnetic nanoparticles was placed in its construction. The structure and morphology of new synthesis compound, were characterized using Ft-IR and scanning electron microscopy, respectively.

Keywords: Chitosan, hydrogel, Molecular imprinting, Cross linker, magnetic nanoparticles, drug delivery