M.A. Thesis:

Evaluation of the association between serum levels of aspirin and oxidative stress markers in children

Background: Childhood obesity has been linked to increased risk of developing type 2 diabetes mellitus (T2DM) in later life, possibly by dysregulation of adipokines. However, available evidence about asprosin, a novel identified adipokine, and glucose homeostasis in children is scarce and contraversial. The aim of this study was to investigate association of asprosin and glucose homeostasis in children. Methos: We recruited 30 normal weight, 30 overweight and 30 obese childeren in this observational study. Demographic and biochemical variables were measured for all participants. Insulin and asprosin concentrations were measured using ELISA method. Homeostatic model assessment (HOMA) of insulin resistance (HOMA-IR), insulin sensitvity (HOMA-S), ?-cell function (HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and triglyceride- glucose index (TyG) were used as glucose homeostasis indeces. Result:Serum levels of asprosin were higher in overweight and obese chihdren than in normal weight children. There was also a significant positive correlation between BMI, insulin, HOMA-IR and TyG in all three groups. In contrast, HDL-C levels decreased significantly with increasing fat mass. Conclusion: Our findings indicated that asprosin concentration was increased in obese childrens. In addition, there was a positive association between asprosin and insulin resistance in childeren with obesity.

Keywords: Keywords: Asprosin, Insulin resistance, Diabetes, Obesity