M.A. Thesis:

An antibiotic resistance in pattern in patients with ear infections to Sabzevar Hospitals

Acute middle ear infection (AOM) is one of the most common causes of acquired hearing impairment, which is increasing. One of the important factors in causing acute otitis media is bacterial infection. The aim of this study was to evaluate the resistance to antibiotics in bacteria that affect acute otitis media in patients with ear infection in Sabzevar. For this purpose, sampling was done from patients referring to hospitals in Sabzevar. Then isolated bacteria were identified from patients. The resistance of these isolates to the antibiotics ciprofloxacin, fluorophenicol, penicillin, cefalexin, gentamicin and oxytetracycline was investigated. Five strains of Pseudomonas aeruginosa, Staphylococcus aureus, Influenza hemophilus, Moraxella catarrh and Streptococcus pneumoniae were isolated from patients. The results of this study showed that Pseudomonas aeruginosa was highly susceptible to ciprofloxacin and fluorophenicin antibiotics compared to other antibiotics used. While Staphylococcus aureus had the highest resistance to Penicillin and Cephalexin antibiotics. Influenza hemofiliosis isolated from patients with ear infections was highly sensitive to fluorophenicin antibiotics and ciprofloxacin, while resistant to cefalexin and penicillin antibiotics. Morellax catarrh also was sensitive to most of the antibiotics used in this study and was most susceptible to ciprofloxin antibiotics and penicillin resistant. The Streptococcus pneumoniae antibody was the most sensitive to gentamicin antibiotics and the least susceptibility to Cephalexin antibiotics. Proteus bacteria isolated from patients was the most sensitive to ciprofloxacin antibiotics, while the penicillin, cefalexin and gentamicin antibiotics were the least susceptible. The results of this study showed that the best antibiotic for Staphylococcus aureus, ciprofloxacin, and the best antibiotic for Streptococcus pneumoniae is the antibiotic gentamicin. In general, ciprofloxacin has been shown to be very good in most bacteria and cephalexin antibiotic has the least effect on tested bacteria

Keywords: Antibiotic resistance - Microbial resistance of the ears - Sabzevar hospitals